Journal: Frontiers in Immunology
Article Title: Integrating multiomics to elucidate the role of chromatin remodeling in glioma and the antitumor mechanisms and therapeutic potential of targeting LMNA
doi: 10.3389/fimmu.2026.1759811
Figure Lengend Snippet: Correlation analysis and expression validation of core genes in the prognostic model. (A) Chord diagram illustrating the co-expression association analysis of core genes ( SPI1 , LMNA , LMNB1 , LMNB2 , CBX8 ) and the prognostic risk score; (B) Heatmap of the correlations between core gene expression and immune cell infiltration; (C) Differences in the mRNA expression of core genes between different risk groups in the CGGA_693 database (*** p < 0.001); (D) Bar charts representing the qRT‒PCR validation results of core genes in glioma and adjacent nontumor tissues (ns, not significant; * p < 0.05, *** p < 0.001, **** p < 0.0001); (E) Boxplots showing the differences in protein expression of core genes between glioma and normal tissues in the UALCAN database (CPTAC data); (F) Representative immunohistochemical (IHC) staining images of core genes in low-grade glioma (LGG) and high-grade glioma (HGG) samples from the HPA database.
Article Snippet: Furthermore, immunohistochemical (IHC) staining data from the Human Protein Atlas (HPA) revealed that LMNA , LMNB1, LMNB2, and CBX8 were robustly expressed across gliomas of varying grades.
Techniques: Expressing, Biomarker Discovery, Gene Expression, Immunohistochemical staining, Immunohistochemistry